By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

greatly revised and up to date, Antisense Drug expertise: ideas, thoughts, and functions, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based cures, and, specifically, antisense therapeutics and learn. reading classes discovered from the scientific trials of first iteration medications, the e-book evaluates the know-how as an entire and provides new instructions and avenues of study and improvement.

Divided into 5 components, the booklet starts with an intensive creation to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. top researchers display the fundamentals of oligonucleotide therapeutics partly through delineating medicinal chemistry, pharmacokinetics, and supply routes akin to liposomal formulations for nucleic acid delivery.  half 3 information hybridization established medicinal drugs and considers the dramatic advances represented by means of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical sessions of gear and mechanisms of motion are defined partially 4 with extra discussions on bettering the second one iteration antisense medicines. the ultimate half delves deeply into healing functions. Contributing authors learn the potential for antisense medicinal drugs for the relief of cardiovascular ailments, metabolic ailments, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely targeted, lucid dialogue of the impressive advances within the box, Antisense Drug know-how: ideas, innovations, and purposes, moment Edition presents the platform for researchers to proceed to aggressively pursue the good chance represented by means of this intriguing technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke


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